Synthesis and pharmacological activity of 3-carboxypicolinic acid amides

A series of substituted amides of 3-carboxypicolinic acid have been synthesized via the interaction of quinolinic acid anhydride with alkyl(aryl)amines. Their structures were studied by ¹H and ¹³C NMR spectroscopy. The direction of the reaction was explained by quantum-chemistry methods. Three compo...

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Published inPharmaceutical chemistry journal Vol. 44; no. 9; pp. 476 - 479
Main Authors Kon'shin, M. E, Syropyatov, B. Ya, Vakhrin, M. I, Neifel'd, P. G, Feshin, V. P, Shurov, S. N, Odegova, T. F
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.12.2010
Springer US
Springer
Subjects
3-carboxypicolinic acid amides
Amides
anticoagulant activity
Anticoagulants (Medicine)
hemostatic activity
Medicine
Nuclear magnetic resonance spectroscopy
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
synthesis
synthesis
3-carboxypicolinic acid amides
hemostatic activity
anticoagulant properties
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Summary:A series of substituted amides of 3-carboxypicolinic acid have been synthesized via the interaction of quinolinic acid anhydride with alkyl(aryl)amines. Their structures were studied by ¹H and ¹³C NMR spectroscopy. The direction of the reaction was explained by quantum-chemistry methods. Three compounds demonstrated hemostatic activity. Two substances exhibited anticoagulant properties. Most substances also exhibited weak bacteriostatic activity.
Bibliography:http://dx.doi.org/10.1007/s11094-010-0495-5
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0495-5