Cytotoxicity and Brine Shrimp Lethality of Rotenoids and Extracts from Sarcolobus globosus

The present study was performed to examine the brine shrimp toxicity and cytotoxic effect of the mangrove plant Sarcolobus globosus. The Et2O and EtOAc extracts were toxic to brine shrimp larvae (LC50 = 1.6 and 4.0 μg/mL) and Caco-2 cells (IC50 = 6.7 and 21.2 μg/mL). Three rotenoids isolated from S....

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Bibliographic Details
Published inNatural product communications Vol. 2; no. 8
Main Authors Wangensteen, Helle, Alamgir, Mahiuddin, Rajia, Sultana, Meza, Trine J., Samuelsen, Anne Berit, Malterud, Karl E.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.08.2007
Subjects
Sarcolobus globosus
brine shrimp lethality
Artemia salina
Rotenoids
cytotoxicity
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Summary:The present study was performed to examine the brine shrimp toxicity and cytotoxic effect of the mangrove plant Sarcolobus globosus. The Et2O and EtOAc extracts were toxic to brine shrimp larvae (LC50 = 1.6 and 4.0 μg/mL) and Caco-2 cells (IC50 = 6.7 and 21.2 μg/mL). Three rotenoids isolated from S. globosus, tephrosin, sarcolobin and 12a-hydroxyrotenone, showed high toxicity in the brine shrimp assay with LC50 values of 2.2, 2.8 and 1.9 μM, respectively.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X0700200810