Silica (NPs) supported Fe (III) as a reusable heterogeneous catalyst for the one-pot synthesis of 1, 4-dihydropyridines under mild conditions

A cheap and recyclable silica (NPs) supported Fe (III) was prepared as heterogeneous catalyst for the synthesis of various substituted 1,4-dihydropyridines via condensation of aldehydes with ethyl acetoacetate and ammonium acetate in ethanol. The products were separated from the catalyst simply by f...

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Published inJournal of chemical sciences (Bangalore, India) Vol. 124; no. 4; pp. 933 - 939
Main Authors SAFAEI-GHOMI, JAVAD, ZIARATI, ABOLFAZL, ZAHEDI, SAFURA
Format Journal Article
LanguageEnglish
Published India Springer-Verlag 01.07.2012
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Heterogeneous catalyst
nano silica
Hantzsch reaction
1,4-dihydropyridine
multi-component
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Summary:A cheap and recyclable silica (NPs) supported Fe (III) was prepared as heterogeneous catalyst for the synthesis of various substituted 1,4-dihydropyridines via condensation of aldehydes with ethyl acetoacetate and ammonium acetate in ethanol. The products were separated from the catalyst simply by filtration and the catalyst could be recycled and reused for several times without noticeable decrease in the catalytic activity. Graphical Abstract A one-pot three-component reaction of aldehyde, ethyl acetoacetate and ammonium acetate catalysed by silica (NPs) supported Fe (III) for the synthesis of 1,4-dihydropyridines is reported.
ISSN:0974-3626
0973-7103
DOI:10.1007/s12039-012-0280-y