A comparative pharmacological investigation of three samples of 'Guduchi ghrita' for adaptogenic activity against forced swimming induced gastric ulceration and hematological changes in albino rats

This study was undertaken to investigate the impact of formulation factors and adjuvants on the expression of biological activity of Tinospora cordifolia (Willd.) Miers. The adaptogenic effect of three samples of Guduchi ghrita, prepared using plain ghee (clarified butter) obtained from three differ...

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Bibliographic Details
Published inInternational journal of Ayurveda research Vol. 1; no. 2; pp. 67 - 72
Main Authors Savrikar, Shriram S, Dole, Vilas, Ravishankar, B, Shukla, Vinay J
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.04.2010
Medknow Publications & Media Pvt. Ltd
Medknow Publications
Subjects
Ayurvedic medicine
Chemical properties
Dosage and administration
Drugs
Gastrointestinal diseases
Hematology
Medicinal plants
Original
Pharmacognosy
Pharmacokinetics
Pharmacology
India
Tinospora cordifolia (Willd.) Miers
rasaayana
Ayurveda
adaptogenic activity
Guduchi ghrita
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Summary:This study was undertaken to investigate the impact of formulation factors and adjuvants on the expression of biological activity of Tinospora cordifolia (Willd.) Miers. The adaptogenic effect of three samples of Guduchi ghrita, prepared using plain ghee (clarified butter) obtained from three different sources was studied in albino rats and compared with expressed juice of stem of Guduchi. The test preparations were evaluated against forced-swimming induced hypothermia, gastric ulceration and changes in the hematological parameters. The test drug given in the form of 'ghrita' produced better effect in comparison to the expressed juice. Among the three 'ghrita' preparations evaluated, only the 'Solapur Guduchi ghrita' (SGG) was found to produce significant inhibition of stress hypothermia and gastric ulceration. The other two preparations 'Nanded Guduchi ghrita' (NGG), and 'Wardha Guduchi ghrita' (WGG) could produce only a marginal effect. In hematological parameters 'Guduchi' juice produced better reversal of the stress-induced changes in comparison to the test 'ghrita' preparations. The present study provides evidence highlighting the importance of formulation factors for the expression of biological activity.
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ISSN:0974-7788
0974-925X
DOI:10.4103/0974-7788.64399