A stereoselective three-component reaction: One-pot synthesis of cis-isoquinolonic acids catalyzed by silica sulfuric acid under mild and heterogeneous conditions

• Published in: Journal of heterocyclic chemistry Vol. 43; no. 1; pp. 187 - 190
• Main Authors: Azizian, J, Mohammadi, AA, Soleimani, E, Karimi, AR, Mohammadizadeh, MR
• Format: Journal Article
• Language: English
• Published: HOBOKEN Wiley 01.01.2006
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; HOMOPHTHALIC ANHYDRIDES; ALDEHYDES; AMINES; DERIVATIVES; IMINES

A mild and stereoselective three-component one-step synthesis of cis-isoquinolonic acid using silica sulfuric acid as a heterogeneous catalyst from an aldehyde, amine and homophthalic anhydride in acetonitrile is described. This new method produces pure products in high yields (81-91%).