A stereoselective three-component reaction: One-pot synthesis of cis-isoquinolonic acids catalyzed by silica sulfuric acid under mild and heterogeneous conditions

A mild and stereoselective three-component one-step synthesis of cis-isoquinolonic acid using silica sulfuric acid as a heterogeneous catalyst from an aldehyde, amine and homophthalic anhydride in acetonitrile is described. This new method produces pure products in high yields (81-91%).

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 43; no. 1; pp. 187 - 190
Main Authors Azizian, J, Mohammadi, AA, Soleimani, E, Karimi, AR, Mohammadizadeh, MR
Format Journal Article
LanguageEnglish
Published HOBOKEN Wiley 01.01.2006
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
HOMOPHTHALIC ANHYDRIDES
ALDEHYDES
AMINES
DERIVATIVES
IMINES
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Summary:A mild and stereoselective three-component one-step synthesis of cis-isoquinolonic acid using silica sulfuric acid as a heterogeneous catalyst from an aldehyde, amine and homophthalic anhydride in acetonitrile is described. This new method produces pure products in high yields (81-91%).
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570430129