Obituary of Dr. Susumu Seino

After graduation, he worked as a physician in the internal medicine department of Kobe University Hospital, Amagasaki Prefectural Hospital and Kitano Hospital for 4 years, during which time he became interested in the field of diabetes through encounters with Drs. Masaki Ikeda and Mikio Yawata. Fort...

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Bibliographic Details
Published inJournal of diabetes investigation Vol. 12; no. 12; pp. 2106 - 2107
Main Author Inagaki, Nobuya
Format Journal Article
LanguageEnglish
Published Japan John Wiley & Sons, Inc 01.12.2021
John Wiley and Sons Inc
Wiley
Subjects
Beta cells
Diabetes
Diabetes mellitus
Electrophysiology
Glucose
Hypoglycemia
Insulin
Internal medicine
Laboratories
Medical research
Molecular biology
Neonates
Obituary
Potassium channels (inwardly-rectifying)
Sulfonylurea
Japan
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Summary:After graduation, he worked as a physician in the internal medicine department of Kobe University Hospital, Amagasaki Prefectural Hospital and Kitano Hospital for 4 years, during which time he became interested in the field of diabetes through encounters with Drs. Masaki Ikeda and Mikio Yawata. Fortunately, with the help of electrophysiologist Dr. Tohru Gonoi, we were able to combine molecular biology and electrophysiology, and succeeded in isolating Kir6.2 and determining the structure of β-cell ATP-sensitive potassium (KATP) channels as a complex of Kir6.2 and SUR1. [...]many patients with neonatal diabetes or congenital hyperinsulinemic hypoglycemia were found to have mutation of the Kir6.2 or SUR1 genes, and it became clear why sulfonylurea rather than insulin is effective in many cases of these diseases.
ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.13686