Synthetic studies connected with the preparation of H+/K+-ATPase inhibitors rabeprazole and lansoprazole

Synthesis of lansoprazole and rabeprazole using common intermediates is devised. The common intermediates, 2-[(4-nitro-3-methylpyridin-2-yl)methanesulfanyl]-1H-benzoimidazole and 2-[(4-chloro-3-methyl-pyridin-2-yl)methanesulfanyl]- 1H-benzoimidazole, were prepared in several ways.

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 43; no. 6; pp. 1447 - 1453
Main Authors Radl, Stanislav, Klecan, Ondrej, Havlicek, Jaroslav
Format Journal Article
LanguageEnglish
Published PROVO HETERO CORPORATION 01.11.2006
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Synthesis of lansoprazole and rabeprazole using common intermediates is devised. The common intermediates, 2-[(4-nitro-3-methylpyridin-2-yl)methanesulfanyl]-1H-benzoimidazole and 2-[(4-chloro-3-methyl-pyridin-2-yl)methanesulfanyl]- 1H-benzoimidazole, were prepared in several ways.
ISSN:0022-152X
DOI:10.1002/jhet.5570430606