METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value

Methyltransferase-like 1 (METTL1) is a methyltransferase that modulates the RNA methylation process and has been increasingly investigated in cancer research over the past decade. The review aims to summarize the diverse roles of METTL1 in various cancers, focusing on the mechanisms underlying tumor...

Full description

Saved in:
Bibliographic Details
Published inOncology reviews Vol. 19; p. 1637372
Main Authors Zhang, Xinyu, Chen, Yuan, Li, Min, Zhou, Xiaomeng, Song, Qingcui
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2025
Subjects
cancer
METTL1
Oncology Reviews
RNA methylation
therapeutic target
tumor mechanism
cancer
therapeutic target
tumor mechanism
METTL1
RNA methylation
Online AccessGet full text

Cover

More Information
Summary:Methyltransferase-like 1 (METTL1) is a methyltransferase that modulates the RNA methylation process and has been increasingly investigated in cancer research over the past decade. The review aims to summarize the diverse roles of METTL1 in various cancers, focusing on the mechanisms underlying tumorigenesis, progression, and metastasis. Furthermore, the therapeutic value and targeting strategies for METTL1 are also discussed to provide the foundation for further development of METTL1-targeted therapies. The article integrates recent research findings to highlight significant discoveries regarding METTL1, emphasizing its potential as a therapeutic target in cancer treatment.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Huhu Zhang, Qingdao University, China
Reviewed by: Xiang Gu, Shanghai Jiao Tong University, China
These authors have contributed equally to this work
Edited by: Peiwei Chai, Shanghai Jiao Tong University, China
ISSN:1970-5557
1970-5565
1970-5557
DOI:10.3389/or.2025.1637372