Enzymatic transformation of biologically active 1,3;1,6-beta-D-glucan. Structure and activity of resulting fragments
The fragmentation of the biologically active 1,3;1,6-beta-D-glucan Antivir by endo-1,3-beta-D-glucanase LIV from crystalline styles of the marine mollusk Spisula sachalinensis was carried out. It was found that low molecular mass oligomers possessing a stabilizing effect on membranes and anti-viral...
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| Published in | Biochemistry (Moscow) Vol. 72; no. 1; pp. 29 - 36 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
01.01.2007
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| Abstract | The fragmentation of the biologically active 1,3;1,6-beta-D-glucan Antivir by endo-1,3-beta-D-glucanase LIV from crystalline styles of the marine mollusk Spisula sachalinensis was carried out. It was found that low molecular mass oligomers possessing a stabilizing effect on membranes and anti-viral activity against tobacco mosaic virus appeared in the process of enzymatic hydrolysis of Antivir. Biological activity of 1,3;1,6-beta-D-glucooligo- and polysaccharides was found to be associated with molecular mass (polymerization degree (n) not less than 14) and with presence of intralinked beta-1,6-connected monosaccharide residues. Probably, decrease in molecular mass is compensated by increase in number of intralinked beta-1,6-connected monosaccharide residues. |
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| AbstractList | The fragmentation of the biologically active 1,3;1,6-beta-D-glucan Antivir by endo-1,3-beta-D-glucanase LIV from crystalline styles of the marine mollusk Spisula sachalinensis was carried out. It was found that low molecular mass oligomers possessing a stabilizing effect on membranes and anti-viral activity against tobacco mosaic virus appeared in the process of enzymatic hydrolysis of Antivir. Biological activity of 1,3;1,6-beta-D-glucooligo- and polysaccharides was found to be associated with molecular mass (polymerization degree (n) not less than 14) and with presence of intralinked beta-1,6-connected monosaccharide residues. Probably, decrease in molecular mass is compensated by increase in number of intralinked beta-1,6-connected monosaccharide residues. |
| Author | Isakov, V V Lapshina, L A Likhatskaya, G N Elyakova, L A Zvyagintseva, T N Reunov, A V Nagorskaya, V P |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17309434$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1021/ac60111a017 10.1038/scientificamerican0985-58 10.1111/j.1439-0434.1996.tb01524.x 10.1104/pp.90.1.208 10.1111/j.1365-2761.1996.tb00385.x 10.1016/0005-2744(72)90980-1 10.1016/S0008-6215(99)00206-2 10.1073/pnas.74.5.1913 10.1016/0144-8617(95)00076-3 10.1016/0031-9422(94)00852-K 10.1016/0008-6215(90)80051-4 10.1021/ar00014a004 10.1016/S0008-6215(00)90304-5 10.1016/0008-6215(86)80036-2 10.1016/S0021-9258(19)52451-6 |
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| Snippet | The fragmentation of the biologically active 1,3;1,6-beta-D-glucan Antivir by endo-1,3-beta-D-glucanase LIV from crystalline styles of the marine mollusk... The fragmentation of the biologically active 1,3; 1,6- beta -D-glucan Antivir by endo-1,3- beta -D-glucanase LIV from crystalline styles of the marine mollusk... |
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| SubjectTerms | Animals Antiviral Agents - chemistry Glucan 1,3-beta-Glucosidase - metabolism Glucans - chemistry Glucans - metabolism Hydrolysis Magnetic Resonance Spectroscopy Mollusca Oligosaccharides - chemistry Spisula - enzymology Spisula sachalinensis Structure-Activity Relationship Substrate Specificity Tobacco mosaic virus |
| Title | Enzymatic transformation of biologically active 1,3;1,6-beta-D-glucan. Structure and activity of resulting fragments |
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