The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas

Inorganic metal ions and the proteins play an essential role in living systems. Different hormones and cellular messengers regulate the hemostasis of organisms. Calcium, magnesium, iron and zinc are abundantly distributed in human bodies and play vital role in many biochemical processes. Albumin and...

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Bibliographic Details
Published inPakistan journal of analytical and environmental chemistry Vol. 20; no. 2; pp. 151 - 160
Main Author Munawar, Aisha
Format Journal Article
LanguageEnglish
Published Jamshoro Knowledge Bylanes 31.12.2019
AsiaNet Pakistan (Pvt) Ltd
National Centre of Excellence in Analytical Chemsitry
Subjects
Albumin
Albumins
Anemia
Atomic absorption analysis
Atomic absorption spectroscopy
Atomic beam spectroscopy
Binding sites
Biochemistry
Blood proteins
Calcium
Enzymes
Ferritin
Hemostasis
Hemostatics
Homeostasis
Hormones
Hyperthyroidism
Iron
Magnesium
Medical research
Metabolism
Metal ions
Physiological aspects
Proteins
Serum proteins
Spectral analysis
Spectrophotometry
Statistical analysis
Studies
Thyroid diseases
Thyroid gland
Zinc
United States > US
Lahore Pakistan
Germany
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Summary:Inorganic metal ions and the proteins play an essential role in living systems. Different hormones and cellular messengers regulate the hemostasis of organisms. Calcium, magnesium, iron and zinc are abundantly distributed in human bodies and play vital role in many biochemical processes. Albumin and ferritin are also the most abundant proteins present in our bodies and carrying out important physiological processes. A disease state or a medical condition can perturb the normal levels of metal ions and proteins in living systems. In the present study, we have analyzed the serum concentration of Ca, Mg, Fe, Zn, albumin and ferritin of hyperthyroid patients. This study includes 184 collected samples (52 normal subjects and 132 hyperthyroid patients), with age group ranging between 11 to 75 years. During sample collection, only those patients were included for whom hyperthyroidism was initially diagnosed but not taking any medicines yet. The hyperthyroid state was determined by the correlation of FT3, FT4 and TSH. Serum Fe, Ca and albumin levels were determined by spectrophotometric method, while Zu and Mg by atomic absorption spectroscopy (AAS) and ferritin by radioimmunology assay (RIA). Obtained results demonstrated the significant differences in the studied parameters as compared to the normal subjects.
ISSN:1996-918X
1996-918X
DOI:10.21743/pjaec/2019.12.19