A 1,8-naphthalimide-derived turn-on fluorescent probe for imaging lysosomal nitric oxide in living cells

Nitric oxide has played an important role in many physiological and pathological processes as a kind of important gas signal molecules. In this work, a new fluorescent probe LysoNO-Naph for detecting NO in lysosomes based on 1,8-naphthalimide was reported. LysoNO-Naph has sub-groups of o-phenylene-...

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Published inChinese chemical letters Vol. 27; no. 9; pp. 1554 - 1558
Main Authors Feng, Wei, Qiao, Qing-Long, Leng, Shuang, Miao, Lu, Yin, Wen-Ting, Wang, Li-Qiu, Xu, Zhao-Chao
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2016
Subjects
Fluorescent probe
Imaging in living cells
Lysosome localized
Naph
Nitric oxide
一氧化氮
气体信号分子
活细胞成像
溶酶体
病理过程
荧光探针
萘酰亚胺
Imaging in living cells
Lysosome localized
Nitric oxide
Fluorescent probe
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Summary:Nitric oxide has played an important role in many physiological and pathological processes as a kind of important gas signal molecules. In this work, a new fluorescent probe LysoNO-Naph for detecting NO in lysosomes based on 1,8-naphthalimide was reported. LysoNO-Naph has sub-groups of o-phenylene- diamine as a NO reaction site and 4-（2-aminoethyl）-morpholine as a lysosome-targetable group. This probe exhibited good selectivity and high sensitivity （4.57 μmol/L） toward NO in a wide pH range from 4 to 12. Furthermore, LysoNO-Naph can be used for imaging NO in lysosomes in living cells.
Bibliography:Fluorescent probe Nitric oxide Lysosome localized Imaging in living cells
Nitric oxide has played an important role in many physiological and pathological processes as a kind of important gas signal molecules. In this work, a new fluorescent probe LysoNO-Naph for detecting NO in lysosomes based on 1,8-naphthalimide was reported. LysoNO-Naph has sub-groups of o-phenylene- diamine as a NO reaction site and 4-（2-aminoethyl）-morpholine as a lysosome-targetable group. This probe exhibited good selectivity and high sensitivity （4.57 μmol/L） toward NO in a wide pH range from 4 to 12. Furthermore, LysoNO-Naph can be used for imaging NO in lysosomes in living cells.
11-2710/O6
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2016.06.016