The role of gated myocardial perfusion scintigraphy (GMPS) in myocarditis: a case report and review of the literature

• Published in: Nuclear medicine review. Central & Eastern Europe Vol. 14; no. 2; pp. 112 - 115
• Main Authors: Javadi, Hamid, Jallalat, Sara, Pourbehi, Gholamreza, Semnani, Shahriar, Mogharrabi, Mehdi, Nabipour, Iraj, Ravanbod, Mohammadreza, Amini, Abdullatif, Assadi, Majid
• Format: Journal Article
• Language: English
• Published: Poland Wydawnictwo Via Medica 01.01.2011
• Subjects: Adult; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography - methods; Case reports; Humans; Male; Myocardial Perfusion Imaging - methods; Myocarditis; Myocarditis - diagnostic imaging; Prognosis; Radiopharmaceuticals; Scintigraphy; Stroke Volume - physiology; Technetium Tc 99m Sestamibi; Tomography; Ventricular Function, Left - physiology
• ISSN: 1506-9680; 1644-4345
• DOI: 10.5603/NMR.2011.00026

Acute myocarditis is one of the most challenging diagnoses and treatments in cardiology. The acute viral myocarditis diagnosis is usually based on high suspicion, history taking, and physical examination. Likewise, the use of chest radiography, electrocardiography (ECG), and echocardiography is helpful in making a final diagnosis, but all are non-specific. In addition, in imaging query, magnetic resonance imaging (MRI) depicts some degree of cardiac inflammation in the course of myocarditis. Myocardial perfusion imaging (MPI) has also been shown to be useful in diagnosis, and this noninvasive technique diminishes the need for myocardial biopsy. The current study presents the diagnostic and prognostic role of MPI in a 25-year-old patientwith suspected myocarditis. The patient underwent gated-technetium- 99m-lablled, methoxyisobutyl isonitrile, single photon emission computed tomography (Gated 99mTc-MIBI SPECT) that showed nonheterogeneous absorption with remarkable decreased radiotracer uptake in the myocardium in both stress and rest phases. In addition, the gated mode demonstrated decreased wall motion and thickening of the myocardium with a sum motion score (SMS) of 28, a sum thickening score (STS) of 15, and a measured LVEF of 34%. The study concludes that 99mTC-MIBI SPECT imaging is a useful modality in the preparation of supplementary diagnostic and prognostic information in viral myocarditis.