Synthesis and Anti-Inflammatory Activity of Tyrosol and Its Structural Analogs

The anti-inflammatory activity of tyrosol and 12 structural analogs including 3 new compounds was determined. Several structure-activity (anti-inflammatory) relationships were found. Adding a tert -butyl substituent to the aromatic ring and increasing the length of the alkyl chain decreased the anti...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 52; no. 11; pp. 907 - 911
Main Authors Krysin, A. P., Tolstikova, T. G., Dolgikh, M. P., Shul’ts, E. E., Pokrovskii, L. M.
Format Journal Article
LanguageEnglish
Published New York Springer US 15.02.2019
Springer
Subjects
Alkyl groups
Anti-inflammatory agents
Cardiology
Medicine
Nonprescription drugs
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Physicians
Steroidal anti-inflammatory agents
tyrosol
anti-inflammatory and antiulcer activity
hydroxyalkylphenols
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Summary:The anti-inflammatory activity of tyrosol and 12 structural analogs including 3 new compounds was determined. Several structure-activity (anti-inflammatory) relationships were found. Adding a tert -butyl substituent to the aromatic ring and increasing the length of the alkyl chain decreased the anti-inflammatory activity. Pronounced antiulcer activity was found for p -tyrosol.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-01924-1