Synthesis and Anti-Inflammatory Activity of Tyrosol and Its Structural Analogs
The anti-inflammatory activity of tyrosol and 12 structural analogs including 3 new compounds was determined. Several structure-activity (anti-inflammatory) relationships were found. Adding a tert -butyl substituent to the aromatic ring and increasing the length of the alkyl chain decreased the anti...
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Published in | Pharmaceutical chemistry journal Vol. 52; no. 11; pp. 907 - 911 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
15.02.2019
Springer |
Subjects | |
Online Access | Get full text |
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Summary: | The anti-inflammatory activity of tyrosol and 12 structural analogs including 3 new compounds was determined. Several structure-activity (anti-inflammatory) relationships were found. Adding a
tert
-butyl substituent to the aromatic ring and increasing the length of the alkyl chain decreased the anti-inflammatory activity. Pronounced antiulcer activity was found for
p
-tyrosol. |
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ISSN: | 0091-150X 1573-9031 |
DOI: | 10.1007/s11094-019-01924-1 |