Direct synthesis of nitriles by Cu/DMEDA/TEMPO-catalyzed aerobic oxidation of primary amines with air

• Published in: Chinese chemical letters Vol. 28; no. 6; pp. 1336 - 1339
• Main Authors: Ma, Xian-Tao, Xu, Hao, Xiao, Ying-Lin, Su, Chen-Liang, Liu, Jian-Ping, Xu, Qing
• Format: Journal Article
• Language: English
• Published: NEW YORK Elsevier B.V 01.06.2017; Elsevier
• Subjects: Aerobic oxidation; Air; Amines; Chemistry; Chemistry, Multidisciplinary; Copper catalysis; Nitriles; Physical Sciences; Science & Technology; Nitriles; Amines; Air; Copper catalysis; Aerobic oxidation; ROOM-TEMPERATURE; CONVERSION; IMINES; HYDRATION; ALCOHOLS; EFFICIENT CATALYST; DEHYDROGENATION; ARYL HALIDES; METAL; AMIDES

By screening the copper catalysts,ligands,and the reaction conditions,a simple CuCl/DMEDA/TEMPO catalyst system readily available from commercial sources is developed for a direct and selective synthesis of the useful nitriles by an aerobic oxidation reaction of primary amines using air as an advant...