Three new pyrrolizidine alkaloids derivatives from Liparis nervosa

Three new pyrrolizidine alkaloids, nervosineⅦ（1）, nervosine Ⅷ（2） and nervosine IX （3） were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses （including 1 D, 2D NMR, and HR-ESI-MS） and chemical methods. Compounds 1-3 were ev...

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Published inChinese chemical letters Vol. 27; no. 5; pp. 757 - 760
Main Authors Huang, Shuai, Zhong, De-Xin, Shan, Lian-Hai, Zheng, Ye-Zi, Zhang, Zhi-Kuan, Bu, Ya-Heng, Ma, Hong-Wen, Zhou, Xian-Li
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.05.2016
Subjects
Liparis nervosa
MCF-7细胞
Nervogenic acid derivatives
Orchidaceae
Pyrrolizidine alkaloids
光谱分析
吡咯
植物提取物
生物碱
细胞毒活性
肿瘤细胞株
衍生物
Liparis nervosa
Orchidaceae
Pyrrolizidine alkaloids
Nervogenic acid derivatives
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Summary:Three new pyrrolizidine alkaloids, nervosineⅦ（1）, nervosine Ⅷ（2） and nervosine IX （3） were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses （including 1 D, 2D NMR, and HR-ESI-MS） and chemical methods. Compounds 1-3 were evaluated for their cytotoxic activity against A549, MCF-7and H460 human cancer cell lines.
Bibliography:11-2710
Three new pyrrolizidine alkaloids, nervosineⅦ（1）, nervosine Ⅷ（2） and nervosine IX （3） were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses （including 1 D, 2D NMR, and HR-ESI-MS） and chemical methods. Compounds 1-3 were evaluated for their cytotoxic activity against A549, MCF-7and H460 human cancer cell lines.
Orchidaceae Liparis nervosa Pyrrolizidine alkaloids Nervogenic acid derivatives
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2016.01.003