Taurospongins B and C, new acetylenic fatty acid derivatives possessing a taurine amide residue from a marine sponge of the family Spongiidae

Two new acetylenic fatty acid derivatives possessing a taurine amide residue, taurospongins B ( 1 ) and C ( 2 ), have been isolated from an Okinawan marine sponge of the family Spongiidae. The gross structures of 1 and 2 were elucidated on the basis of their spectral data, especially 2D NMR and FABM...

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Published inRSC advances Vol. 4; no. 22; pp. 11073 - 11079
Main Authors Kubota, Takaaki, Suzuki, Haruna, Takahashi-Nakaguchi, Azusa, Fromont, Jane, Gonoi, Tohru, Kobayashi, Jun'ichi
Format Journal Article
LanguageEnglish
Published 01.01.2014
Subjects
Amides
Derivatives
Fatty acids
Marine
Residues
Spectra
Sponges
Two dimensional
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Summary:Two new acetylenic fatty acid derivatives possessing a taurine amide residue, taurospongins B ( 1 ) and C ( 2 ), have been isolated from an Okinawan marine sponge of the family Spongiidae. The gross structures of 1 and 2 were elucidated on the basis of their spectral data, especially 2D NMR and FABMS/MS data. The absolute configurations for 1 and 2 were established by chemical means. Taurospongin C ( 2 ) showed inhibitory activity against Cryptococcus neoformans .
Bibliography:ObjectType-Article-1
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ISSN:2046-2069
2046-2069
DOI:10.1039/C3RA47796G