Metabolic evaluation of young women with congenital adrenal hyperplasia

• Published in: Arquivos brasileiros de endocrinologia e metabologia Vol. 55; no. 8; pp. 646 - 652
• Main Authors: Schnaider-Rezek, Gabrielle Sormanti, Lemos-Marini, Sofia Helena Valente de, Baptista, Maria Tereza Matias, Guerra-Júnior, Gil, Morcillo, André Moreno, Mello, Maricilda Palandi de, Oliveira, Laurione Cândido de, D'Souza-Li, Lilia
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Sociedade Brasileira de Endocrinologia e Metabologia 01.11.2011
• Subjects: Adolescent; Adrenal Hyperplasia, Congenital - drug therapy; Adrenal Hyperplasia, Congenital - metabolism; Blood Glucose - metabolism; Body Mass Index; ENDOCRINOLOGY & METABOLISM; Female; Glucocorticoids - administration & dosage; Humans; Insulin - metabolism; Insulin Resistance - physiology; Lipids - blood; Obesity, Abdominal - diagnosis; Statistics, Nonparametric; Waist Circumference - physiology; Young Adult; dislipidemia; Hiperplasia adrenal congênita; resistência insulínica; Congenital adrenal hyperplasia; dyslipidemia; insulin resistance; obesity; obesidade
• ISSN: 0004-2730; 1677-9487; 1677-9487; 0004-2730
• DOI: 10.1590/S0004-27302011000800021

To evaluate insulin resistance and lipid profile in women with congenital adrenal hyperplasia (CAH) caused by classical 21-hydroxylase deficiency (21OHD), and their association with body mass index (BMI) and corticosteroid dosage. We assessed BMI, waist circumference, current glucocorticoid dosage, glucose, insulin and lipid profile in eighteen young women (mean ± SD, 19.3 ± 3.0 years) with 21OHD CAH. BMI was normal in 12 patients, 5 of them were overweight, and 1 was obese. Waist circumference was high in 7 patients. Fasting insulin and HOMA-IR were elevated in seven and eight patients, respectively. Total cholesterol and triglycerides were high in only two patients, and HDL-cholesterol was low in four. Insulin resistance was not associated with BMI, waist circumference or glucocorticoid dose. Young women with 21OHD CAH had infrequent dyslipidemia, but had a higher prevalence of insulin resistance and central obesity, that were independent of BMI or corticosteroid dosage.