Microemulsion-based media as novel drug delivery systems

Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide r...

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Bibliographic Details
Published inAdvanced drug delivery reviews Vol. 64; pp. 175 - 193
Main Authors Lawrence, M. Jayne, Rees, Gareth D.
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier B.V 01.12.2012
Elsevier
Subjects
Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Microemulsion
Drug carrier
Pharmaceutical technology
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Summary:Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. In order to appreciate the potential of microemulsions as delivery vehicles, this review gives an overview of the formation and phase behaviour and characterization of microemulsions. The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2012.09.018