A Compact Miniaturized Flow System Based on Low-Temperature Co-fired Ceramic Technology Coupled to LED Mini-photometer for Determination of Dipyrone in Pharmaceutical Formulations

• Published in: Journal of the Brazilian Chemical Society Vol. 24; no. 5; pp. 847 - 855
• Main Authors: Suarez, Willian T., Pessoa-Neto, Osmundo D., Santos, Vagner B. dos, Nogueira, Ana Rita de A., Faria, Ronaldo C., Fatibello-Filho, Orlando, Chamarro, Julián A.
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira de Química 01.05.2013
• Subjects: CHEMISTRY, MULTIDISCIPLINARY; flow injection analysis; LED photometer; dipyrone; low-temperature co-fired ceramic; analytical microsystem
• ISSN: 0103-5053; 1678-4790
• DOI: 10.5935/0103-5053.20130112

In this work, an analytical microsystem based on LTCC (low-temperature co-fired ceramic) technology with monolithic incorporation of an optical flow cell for determination of dipyrone in pharmaceuticals is described. The detection system is based on the formation of a blue chromophore between dipyrone and Fe(III) photometrically monitored at 630 nm using a lab-made LED mini-photometer constructed with a light emitting diode as a radiation source and a Si photodiode as a detector. The lab-made mini-photometer elaborated presented a good performance in regard to high signal/noise ratio, low drift and good sensitivity. The analytical curve was linear in the dipyrone concentration range from 1.0 × 10-4 to 3.5 × 10-3 mol L-1, limit of detection of 4.5 × 10-5 mol L-1 and total time of analyses of 20 s yielding an analytical frequency of 195 h-1 with a low waste generation per analysis (480 µL).