Grincamycins I - K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32

Three new angucycline glycosides, designated grincamycin I (1: ), J (2: ), and K (3: ), together with the known congener A-7884 (4: ), were isolated from marine-derived actinomycete SCSIO LR32. The structures of the new compounds were elucidated by comprehensive spectral data analysis. Compounds 2:...

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Published inPlanta medica Vol. 84; no. 3; p. 201
Main Authors Lai, Zhenzhu, Yu, Jianchen, Ling, Huiping, Song, Yongxiang, Yuan, Jie, Ju, Jianhua, Tao, Yiwen, Huang, Hongbo
Format Journal Article
LanguageEnglish
Published Germany 01.02.2018
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Summary:Three new angucycline glycosides, designated grincamycin I (1: ), J (2: ), and K (3: ), together with the known congener A-7884 (4: ), were isolated from marine-derived actinomycete SCSIO LR32. The structures of the new compounds were elucidated by comprehensive spectral data analysis. Compounds 2: and 4: exhibited antitumor activity against human cancer cells MDA-MB-435, MDA-MB-231, NCI-H460, HCT-116 and HepG2, and human normal breast epithelial cell MCF10A with IC values ranging from 0.4 to 6.9 µM. In addition, A-7884 (4: ) demonstrated antimicrobial activity against with an MIC value of 1.95 µg/mL.
ISSN:1439-0221
DOI:10.1055/s-0043-119888