Grincamycins I - K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32
Three new angucycline glycosides, designated grincamycin I (1: ), J (2: ), and K (3: ), together with the known congener A-7884 (4: ), were isolated from marine-derived actinomycete SCSIO LR32. The structures of the new compounds were elucidated by comprehensive spectral data analysis. Compounds 2:...
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Published in | Planta medica Vol. 84; no. 3; p. 201 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
01.02.2018
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Online Access | Get more information |
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Summary: | Three new angucycline glycosides, designated grincamycin I (1: ), J (2: ), and K (3: ), together with the known congener A-7884 (4: ), were isolated from marine-derived actinomycete
SCSIO LR32. The structures of the new compounds were elucidated by comprehensive spectral data analysis. Compounds 2: and 4: exhibited antitumor activity against human cancer cells MDA-MB-435, MDA-MB-231, NCI-H460, HCT-116 and HepG2, and human normal breast epithelial cell MCF10A with IC
values ranging from 0.4 to 6.9 µM. In addition, A-7884 (4: ) demonstrated antimicrobial activity against
with an MIC value of 1.95 µg/mL. |
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ISSN: | 1439-0221 |
DOI: | 10.1055/s-0043-119888 |