Acute steroidogenic responsiveness to human luteinizing hormone in hypogonadotropic hypogonadism

The responses of circulating levels of androgens, estrogens, and their C-21 biosynthetic precursors to a 6-h constant infusion of human Lh (hLH; 2000 IU) were studied in four males with hypogonadotropic hypogonadism (HH) and compared with those in normal male controls. Although similar levels of cir...

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Published inThe journal of clinical endocrinology and metabolism Vol. 51; no. 6; p. 1269
Main Authors Wang, C, Paulsen, C A, Hopper, B R, Rebar, R W, Yen, S S
Format Journal Article
LanguageEnglish
Published United States 01.12.1980
Subjects
17-alpha-Hydroxypregnenolone - blood
Adult
Estradiol - blood
Estrone - blood
Gonadal Steroid Hormones - blood
Humans
Hydroxyprogesterones - blood
Hypogonadism - blood
Luteinizing Hormone - blood
Luteinizing Hormone - pharmacology
Male
Testis - drug effects
Testosterone - blood
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Summary:The responses of circulating levels of androgens, estrogens, and their C-21 biosynthetic precursors to a 6-h constant infusion of human Lh (hLH; 2000 IU) were studied in four males with hypogonadotropic hypogonadism (HH) and compared with those in normal male controls. Although similar levels of circulating LH were achieved, the initial and secondary increases in testosterone were significantly greater in the hypogonadotropic subjects than in the normal controls. In contrast, the responses of estradiol, estrone, 17 alpha-hydroxyprogesterone, and 17 alpha-hydroxypregnenolone to exogenous hLH were significantly lower in HH than in normal controls. The data demonstrate a different pattern of testicular steroidogenic responsiveness after pharmacological doses of hLH, with increased concentrations of circulating testosterone in subjects with HH compared to a disproportionate increase in estrogen and progestin levels in normal men.
ISSN:0021-972X
DOI:10.1210/jcem-51-6-1269