Fenofibrate-induced rhabdomyolysis in a patient with chronic kidney disease: an unusual presenting feature of hypothyroidism

Clinical and most often moderate skeletal muscle involvement is a frequent problem in adults with hypothyroidism, and includes a number of different manifestations. Severe involvement with rhabdomyolysis, however, is very rare, and only a few cases have been reported to date, most of them with an ad...

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Published inArquivos brasileiros de endocrinologia e metabologia Vol. 53; no. 3; pp. 383 - 386
Main Authors Sousa, Alessandra Alves de, Kronit, Hans Stauber, Neves, Francisco de Assis Rocha, Amato, Angélica Amorim
Format Journal Article
LanguageEnglish
Published Brazil Sociedade Brasileira de Endocrinologia e Metabologia 01.04.2009
Subjects
ENDOCRINOLOGY & METABOLISM
Fenofibrate - adverse effects
Humans
Hypertriglyceridemia - drug therapy
Hypolipidemic Agents - adverse effects
Hypothyroidism - complications
Male
Middle Aged
Renal Insufficiency, Chronic - complications
Rhabdomyolysis - chemically induced
chronic kidney disease
hypothyroidism
hipotireoidismo
Rabdomiólise
Rhabdomyolysis
fibrato
fibrate
doença renal crônica
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Summary:Clinical and most often moderate skeletal muscle involvement is a frequent problem in adults with hypothyroidism, and includes a number of different manifestations. Severe involvement with rhabdomyolysis, however, is very rare, and only a few cases have been reported to date, most of them with an additional factor of muscle injury. We described a patient with stage 3 chronic kidney disease who presented with rhabdomyolysis while taking fenofibrate, and was found to have hypothyroidism. We also highlighted the importance of excluding the diagnosis of thyroid dysfunction before treatment with lipid-lowering agents.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0004-2730
1677-9487
1677-9487
0004-2730
DOI:10.1590/S0004-27302009000300015