Uncinatic acids A-C, three new carboxylated flavonoids from Selaginella uncinata

Three new carboxylated flavonoids, uncinatic acids A-C（1–3）, were isolated from the whole herb of Selaginella uncinata. Their structures were established on the basis of extensive NMR analysis including1 D, 2D NMR experiments and HR-ESIMS techniques. All of them share the carboxylation structural ch...

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Published inChinese chemical letters Vol. 28; no. 7; pp. 1465 - 1468
Main Authors Liu, Rui, Zou, Hui, Xu, Ping-Sheng, Zou, Zhen-Xing, Li, Jing, Cheng, Fei, Liu, Rui-Huan, Zhou, Gan, Xu, Kang-Ping, Tan, Gui-Shan
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.07.2017
Subjects
A549细胞
Anticancer
Carboxylated flavonoids
Cytotoxicity
Furanoflavonoids
Selaginella
Selaginella uncinata
Uncinatic acids A-C
交流
体外培养
核磁共振分析
核磁共振实验
结构特征
羧基化
黄酮类化合物
Uncinatic acids A-C
Furanoflavonoids
Selaginella uncinata
Cytotoxicity
Carboxylated flavonoids
Anticancer
Selaginella
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Summary:Three new carboxylated flavonoids, uncinatic acids A-C（1–3）, were isolated from the whole herb of Selaginella uncinata. Their structures were established on the basis of extensive NMR analysis including1 D, 2D NMR experiments and HR-ESIMS techniques. All of them share the carboxylation structural characteristic. Compounds 1 and 2 belong to novel naturally occuring furanoflavonoids which is firstly reported in genus Selaginella. Such furanoflavonoids with dicarboxylic acid structrure have never been discovered before. In addition, the isolates were tested for their cytotoxicity against A549 and BGC-823 cell lines in vitro.
Bibliography:Three new carboxylated flavonoids, uncinatic acids A-C（1–3）, were isolated from the whole herb of Selaginella uncinata. Their structures were established on the basis of extensive NMR analysis including1 D, 2D NMR experiments and HR-ESIMS techniques. All of them share the carboxylation structural characteristic. Compounds 1 and 2 belong to novel naturally occuring furanoflavonoids which is firstly reported in genus Selaginella. Such furanoflavonoids with dicarboxylic acid structrure have never been discovered before. In addition, the isolates were tested for their cytotoxicity against A549 and BGC-823 cell lines in vitro.
Selaginella uncinata Selaginella Uncinatic acids A-C Carboxylated flavonoids Furanoflavonoids Anticancer Cytotoxicity
11-2710/O6
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2017.03.004