Is tumour location a prognostic factor for pharmacological treatment in patients with desmoid-type fibromatosis? a systematic review

• Published in: Japanese journal of clinical oncology Vol. 50; no. 9; pp. 1032 - 1036
• Main Authors: Koike, Hiroshi, Hamada, Shunsuke, Sakai, Tomohisa, Shimizu, Koki, Yoshida, Masahiro, Nishida, Yoshihiro
• Format: Journal Article
• Language: English
• Published: 01.09.2020
• ISSN: 1465-3621; 1465-3621
• DOI: 10.1093/jjco/hyaa078

Abstract Background The mainstay of the treatment for desmoid-type fibromatoses has been shifting from surgery to drug treatment, making accurate prediction of the efficacy of drug treatment of extreme importance. On the other hand, desmoid-type fibromatoses arise everywhere in the body. The purpose of this systematic review was to address the clinical question of whether tumour location has an impact on the efficacy of drug treatment. Methods A literature search from January 1990 to August 2017 was conducted. Four reviewers independently assessed and screened the literature for eligibility and determined the final articles. They rated each report according to the Grading of Recommendations Development and Evaluation approach. Based on the quality of ‘Body of Evidence’, our clinical guideline committee developed a recommendation for the clinical question. Results In total, 128 articles were extracted. After the screenings, 5 were chosen for the final evaluation. The drugs used in these articles were one each of toremifene, sorafenib, and methotrexate and vinblastine and of meloxicam. There were no randomized controlled trials, and two prospective and three retrospective case series were included. Therapeutic effects were observed slightly more markedly in extremity using meloxicam or methotrexate and vinblastine. In contrast, the efficacy of toremifene was slightly higher in non-extremity. However, the evidence level of all of the reports was judged to be low. Conclusions Considering the low evidence level, we concluded that the site-specific therapeutic effects of drugs could not be confirmed in desmoid-type fibromatoses.