Limonin Derivatives: Synthesis Using Methodology in Solution and Heterogeneous Medium and Evaluation of the Antimicrobial Activity
We herein described the preparation of a novel series of limonin derivatives (modification in A-ring), which was synthesized efficiently using methodology in solution as well as in heterogeneous medium (K-10). In addition, we obtained derivatives by inserting the 1,2,3-triazole nucleus via click rea...
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Published in | Journal of the Brazilian Chemical Society Vol. 27; no. 1; pp. 161 - 178 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English Portuguese |
Published |
SAO PAULO
Soc Brasileira Quimica
01.01.2016
Sociedade Brasileira de Química |
Subjects | |
Online Access | Get full text |
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Summary: | We herein described the preparation of a novel series of limonin derivatives (modification in A-ring), which was synthesized efficiently using methodology in solution as well as in heterogeneous medium (K-10). In addition, we obtained derivatives by inserting the 1,2,3-triazole nucleus via click reaction and also prepared derivatives from reactions with limonin-7-oxime. All compounds were submitted to investigation of the antimicrobial activity against a collection of microorganisms. The results of the antimicrobial activity, in general, demonstrated that a relevant number of synthetic derivatives presented higher activity than the natural product. |
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ISSN: | 0103-5053 1678-4790 1678-4790 |
DOI: | 10.5935/0103-5053.20150266 |