Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China

• Published in: Chinese medical journal Vol. 124; no. 14; pp. 2113 - 2116
• Main Authors: Hao, Ying, Wu, Bao-gang, Shi, Jin, Chen, Yan-li, Sun, Zhao-qing, Zheng, Li-qiang, Zhang, Xin-gang, Geng, Ning, Li, Tie-jun, Li, Hong, Sun, Ying-xian
• Format: Journal Article
• Language: English
• Published: China Department of Cardiology, First Hospital of China Medical University, Shenyang, Liaoning 110001, China 20.07.2011
• Subjects: Aged; Female; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Glutathione Peroxidase - genetics; GPX; Humans; Hypertension - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; 中国; 农村地区; 单核苷酸多态性; 原发性高血压; 标签; 汉人; 辽宁省; GPx-3 gene; association; Han Chinese; hypertension
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2011.14.006

Background Genetic mechanisms contribute to blood pressure regulation. This study investigated whether glutathione peroxidase （GPx-3） tag single nucleotide polymorphisms （SNPs） are associated with hypertension in the rural areas of Fuxin county, Liaoning province, China.Methods Indigenous Fuxin Han people participated, 523 unrelated hypertensives and 547 controls were recruited. All tag SNPs of GPx-3 gene were selected. We estimated SNP allele frequency in DNA pools with pyrosequencing.Results Before Bonferroni correction, C allele frequency for rs8177417 was significantly higher in hypertensives than those in controls （23.4% vs. 19.3%, P=0.014）; T allele frequency for rs3828599 was significantly lower in hypertensives than those in controls （35.6% vs. 40.8%,P=0.009）. However, when a Bonferroni correction for multiple testing was applied, only the polymorphisms rs3828599 of GPx-3 gene was associated with hypertension （P=0.045, OR： 0.833, 95%CI： 0.695-0.998）.Conclusion The polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin, Liaoning.