The mechanism of increasing l-asparaginase activity in the rat liver, chick liver and chick kidney

• Published in: Comparative biochemistry and physiology. B, Comparative biochemistry Vol. 66; no. 1; pp. 139 - 142
• Main Authors: Penner, Mike H., Coon, Craig N.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 1980
• Subjects: animal physiology
• ISSN: 0305-0491
• DOI: 10.1016/0305-0491(80)90096-6

1. 1. The increase in l-asparaginase specific activity in liver of Sprague-Dawley Rats, Rattus norvegicus, and liver and kidney of Hubbard broiler chicks, Gallus domesticus, fed 75% protein diets or fasted was examined using kinetic studies. 2. 2. The 2.6-fold increase in asparaginase specific activity in liver of rats fed 75% protein diets was dependent upon a 6.8-fold elevation of the asparaginase synthesis rate. 3. 3. The 3.1-fold increase in asparaginase specific activity in liver of chicks fed 75% protein diets was due to a 3-fold reduction in the asparaginase degradation rate constant. 4. 4. The increase in asparaginase specific activity in the kidney of chicks fed high protein diets or fasted is due to an increase in the synthesis rate for asparaginase.