Statistical methods for the analysis of high-throughput data based on functional profiles derived from the Gene Ontology

The increasing availability of high-throughput data, that is, massive quantities of molecular biology data arising from different types of experiments such as gene expression or protein microarrays, leads to the necessity of methods for summarizing the available information. As annotation quality im...

Full description

Saved in:
Bibliographic Details
Published inJournal of statistical planning and inference Vol. 137; no. 12; pp. 3975 - 3989
Main Authors SANCHEZ, Alex, SALICRU, Miquel, OCANA, Jordi
Format Journal Article Conference Proceeding
LanguageEnglish
Russian
Published Lausanne Elsevier B.V 01.12.2007
New York,NY Elsevier Science
Amsterdam
Subjects
Functional profile
Gene ontology
Microarrays
Gene ontology
Functional profile
Microarrays
Online AccessGet full text

Cover

More Information
Summary:The increasing availability of high-throughput data, that is, massive quantities of molecular biology data arising from different types of experiments such as gene expression or protein microarrays, leads to the necessity of methods for summarizing the available information. As annotation quality improves it is becoming common to rely on biological annotation databases, such as the Gene Ontology (GO), to build functional profiles which characterize a set of genes or proteins using the distribution of their annotations in the database. In this work we describe a statistical model for such profiles, provide methods to compare profiles and develop inferential procedures to assess this comparison. An R-package implementing the methods will be available at publication time.
ISSN:0378-3758
1873-1171
DOI:10.1016/j.jspi.2007.04.015