Changes in serum levels of IGF-1 and in growth following adenotonsillectomy in children

• Published in: International journal of pediatric otorhinolaryngology Vol. 72; no. 7; pp. 1065 - 1069
• Main Authors: Kang, Jun-Myung, Auo, Hyeon-Jin, Yoo, Young-Hwa, Cho, Jin-Hee, Kim, Byung-Guk
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.07.2008
• Subjects: Adenoidectomy; Adenoids - pathology; Adenotonsillar hypertrophy; Adenotonsillectomy; Airway Obstruction - etiology; Airway Obstruction - surgery; Body Height; Body Mass Index; Body Weight; Child; Child, Preschool; Children; Female; Follow-Up Studies; Growth; Humans; Hypertrophy; IGF-1; Insulin-Like Growth Factor I - analysis; Male; Otolaryngology; Palatine Tonsil - pathology; Pediatrics; Sleep Apnea, Obstructive - etiology; Sleep Apnea, Obstructive - surgery; Sleep disorders; Tonsillectomy; Sleep disorders; IGF-1; Children; Adenotonsillectomy; Growth; Adenotonsillar hypertrophy
• ISSN: 0165-5876; 1872-8464
• DOI: 10.1016/j.ijporl.2008.03.015

Summary Objective Adenotonsillar hypertrophy can cause upper airway obstruction and may be associated with growth delay in children. The objective of this study was to evaluate the long-term effects of adenotonsillectomy on height, weight, and body mass index (BMI) in children with sleep-disordered breathing (SDB). Methods Fifty-two children (mean age 6.2 ± 2.3 years) clinically diagnosed with SDB were enrolled. Children were diagnosed and scheduled for adenotonsillectomy (T&A) based on their responses to the validated, 22-item Sleep Related Breathing Disorder (SRDB) scale and a physical examination that showed adenotonsillar hypertrophy. Weight, height, and BMI were evaluated before and 5 years after T&A. Serum levels of insulin-like growth factor-1 (IGF-1) were measured before and 1 month after T&A. Results Serum levels of IGF-1 were significantly higher at 1 month after T&A compared to before T&A ( p < 0.001). Thirty children (58%) returned for follow-up testing 5 years later. Their Z scores (standard deviation scores) for weight, height, and BMI of 30 children were significantly higher 5 years after T&A compared to before T&A ( p < 0.01). Conclusion Children with SDB who undergo adenotonsillectomy show significant, long-term increases in weight, height and BMI, as well as a significant increase in serum levels of IGF-1.