New cytotoxic apigenin derivatives from Selaginella doederleinii

75%aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated,and two new apigenin derivatives,doederflavones A（1） and B（2）,together with ten known compounds（3-12） were characterized.Their structures were assigned by extensive spectroscopic methods including 1D/2D NMR and...

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Bibliographic Details
Published inChinese chemical letters Vol. 28; no. 5; pp. 931 - 934
Main Authors Zou, Zhen-Xing, Tan, Gui-Shan, Zhang, Guo-Gang, Yu, Xia, Xu, Ping-Sheng, Xu, Kang-Ping
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.05.2017
Subjects
Apigenin derivatives
Cytotoxicity
Doederflavones A and B
IC50
乙醇水溶液
二维核磁共振
化合物
细胞毒性
芳基取代
芹菜素
衍生物
Apigenin derivatives
Cytotoxicity
Doederflavones A and B
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Summary:75%aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated,and two new apigenin derivatives,doederflavones A（1） and B（2）,together with ten known compounds（3-12） were characterized.Their structures were assigned by extensive spectroscopic methods including 1D/2D NMR and HR-ESIMS.Compounds 1-6 bear an aryl substituent at the C-8 or C-6 positions in ring A of apigenin skeleton.Compounds 1 and 2 were evaluated for their in vitro cytotoxicity against four human cancer cell lines A549,MCF-7,SMMC-7721,and LoVo,both of which exhibited significant cytotoxicity against A549 with IC50 values of 0.82 μmol/L and 1.32 μmol/L,respectively.
Bibliography:Apigenin derivatives Doederflavones A and B Cytotoxicity
11-2710/O6
75%aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated,and two new apigenin derivatives,doederflavones A（1） and B（2）,together with ten known compounds（3-12） were characterized.Their structures were assigned by extensive spectroscopic methods including 1D/2D NMR and HR-ESIMS.Compounds 1-6 bear an aryl substituent at the C-8 or C-6 positions in ring A of apigenin skeleton.Compounds 1 and 2 were evaluated for their in vitro cytotoxicity against four human cancer cell lines A549,MCF-7,SMMC-7721,and LoVo,both of which exhibited significant cytotoxicity against A549 with IC50 values of 0.82 μmol/L and 1.32 μmol/L,respectively.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2017.01.011