The c-erb-A gene encodes a thyroid hormone receptor

The cDNA sequence of human c-erb-A, the cellular counterpart of the viral oncogene v-erb-A, indicates that the protein encoded by the gene is related to the steroid hormone receptors. Binding studies with the protein show it to be a receptor for thyroid hormones.

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Bibliographic Details
Published inNature (London) Vol. 324; no. 6098; p. 641
Main Authors Weinberger, C, Thompson, C C, Ong, E S, Lebo, R, Gruol, D J, Evans, R M
Format Journal Article
LanguageEnglish
Published England 18.12.1986
Subjects
Amino Acid Sequence
Base Sequence
Binding, Competitive
Cell Transformation, Neoplastic
DNA - analysis
Genes
Humans
Kinetics
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - immunology
Proto-Oncogenes
Receptors, Thyroid Hormone - genetics
Receptors, Thyroid Hormone - metabolism
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Summary:The cDNA sequence of human c-erb-A, the cellular counterpart of the viral oncogene v-erb-A, indicates that the protein encoded by the gene is related to the steroid hormone receptors. Binding studies with the protein show it to be a receptor for thyroid hormones.
ISSN:0028-0836
DOI:10.1038/324641a0