Recyclable europium functionalized metal-organic fluorescent probe for detection of tryptophan in biological fluids and food products

• Published in: Analytica chimica acta Vol. 1180; p. 338897
• Main Authors: Zhong, Yu-Fei, Bao, Guang-Ming, Xia, Yi-Fan, Peng, Xiong-Xin, Peng, Jin-Feng, He, Jia-Xin, Lin, Shuai, Zeng, Lintao, Fan, Qing, Xiao, Wei, Yuan, Hou-Qun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 02.10.2021
• Subjects: Eu3+-functionalized; Metal-organic framework; Recyclable fluorescent probe; Tryptophan; Tryptophan; Eu3+-functionalized; Recyclable fluorescent probe; Metal-organic framework
• ISSN: 0003-2670; 1873-4324; 1873-4324
• DOI: 10.1016/j.aca.2021.338897

An europium functionalized metal-organic fluorescent probe, Eu3+@UiO-66-FDC was constructed by post-synthetic modification through coordination interactions. Eu3+@UiO-66-FDC displayed high selectivity and sensitivity toward Tryptophan (Trp) among all the 20 natural amino acids and other general compounds in food and biological samples, with a wide linear concentration range (0–1000 μM), low detection limit (0.29 μM), and a rapid response (<1 min). Besides, this probe was utilized to detect Trp in rabbit blood serum and milk samples with good recoveries, which were verified by high-performance liquid chromatography (HPLC). Notably, this fluorescent probe proved to be a recyclable material. Hence, this work provides a reliable and recyclable fluorescent probe applicable toward the detection of Trp in biological fluids and/or food products. [Display omitted] •An Eu3+-functionalized probe has been explored for specific recognizing tryptophan.•The probe exhibits low detection limit (0.29 μM) and fast response (<1 min).•The probe can be recycled and reused to monitor tryptophan.•The probe could be applied in biological fluids and food production.