Differential pulse voltammetric determination of nimesulide in pharmaceutical formulation and human serum at glassy carbon electrode modified by cysteic acid/CNTs based on electrochemical oxidation of l-cysteine

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 42; no. 2; pp. 237 - 244
• Main Authors: Wang, Chengyin, Shao, Xiaoqiu, Liu, Qingxiu, Qu, Qishu, Yang, Gongjun, Hu, Xiaoya
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 18.09.2006; Elsevier Science
• Subjects: Analysis; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Carbon nanotube; Cysteic acid; Fundamental and applied biological sciences. Psychology; General pharmacology; Human serum; l-cysteine; Medical sciences; Nimesulide; Pharmacology. Drug treatments; Voltammetry; Carbon nanotube; Human serum; Cysteic acid; Voltammetry; l-cysteine; Nimesulide; Prostaglandin-endoperoxide synthase; Biological fluid; Cysteine; Determination; Electrodes; L-cysteine; Oxidation; Electrochemical reaction; Quantitative analysis; Modified material; Human; Thiol; Enzyme; Differential impulse voltamperometry; Enzyme inhibitor; Metabolism; Carbon; Sulfur containing aminoacid; Non steroidal antiinflammatory agent; Analgesic; Antipyretic; Dosage form; Oxidoreductases; Pharmacokinetics; Glassy state

Carbon nanotubes (CNTs) and cysteic acid based on electrochemical oxidation of l-cysteine (CySH) to form a novel composite thin film material at a glassy carbon electrode (GCE) for electroanalytical determination of nimesulide. The determination of nimesulide at the composite modified electrode with...