Enzyme catalysed deracemisation and dynamic kinetic resolution reactions

New catalysts and reaction conditions have been developed for the dynamic kinetic resolution or deracemisation of racemic mixtures of chiral compounds. Specific functional groups that lend themselves particularly well to this approach include chiral secondary alcohols, alpha-amino acids, amines and...

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Bibliographic Details
Published inCurrent opinion in chemical biology Vol. 8; no. 2; pp. 114 - 119
Main Author Turner, Nicholas J
Format Journal Article
LanguageEnglish
Published England 01.04.2004
Subjects
Bacteria - enzymology
Biotransformation
Catalysis
Enzymes - chemistry
Enzymes - metabolism
Fungal Proteins
Kinetics
Lipase - chemistry
Lipase - metabolism
Molecular Structure
Organic Chemicals - metabolism
Stereoisomerism
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Summary:New catalysts and reaction conditions have been developed for the dynamic kinetic resolution or deracemisation of racemic mixtures of chiral compounds. Specific functional groups that lend themselves particularly well to this approach include chiral secondary alcohols, alpha-amino acids, amines and carboxylic acids. A general theme of these processes is the combination of an enantioselective enzyme with a chemical reagent, the latter being used either to racemise the unreactive enantiomer or alternatively recycle an intermediate in the deracemisation process. In some examples of dynamic kinetic resolution, a second enzyme (racemase) is used to interconvert the enantiomers of the starting material.
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ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2004.02.001