The Correlation of Antibacterial Peptides Concentration in Umbilical Cord Blood and Early Onset Sepsis in Preterm Infants

Umbilical cord blood from singleton preterm infants was collected during delivery, and the concentration of LL37 was measured. C-reactive protein (CRP), white blood cell count (WBC), platelets (PLT), and mean platelet volume (MPV) were determined within 3 days after birth. The differences in LL37, C...

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Published inFrontiers in pediatrics Vol. 10; p. 903319
Main Authors Miao, Jiayu, Ren, Zhuxiao, Zhong, Zhicheng, Xu, Fang, Wang, Jianlan, Yang, Jie
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.05.2022
Subjects
antibacterial peptide
bio-maker
LL37
Pediatrics
preterm infants
sepsis
antibacterial peptide
preterm infants
bio-maker
sepsis
LL37
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Summary:Umbilical cord blood from singleton preterm infants was collected during delivery, and the concentration of LL37 was measured. C-reactive protein (CRP), white blood cell count (WBC), platelets (PLT), and mean platelet volume (MPV) were determined within 3 days after birth. The differences in LL37, CRP, WBC, PLT, and MPV levels between the two groups were compared. Pearson correlation method was used to analyze the correlation between these factors. The early individual value of each detected index for early onset sepsis was analyzed by ROC curve. The level of LL37 in umbilical cord blood of sepsis group was significantly higher than those in the control group (383.85 ± 46.71 vs. 252.37 ± 83.30 ng/ml). Meanwhile, the levels of CRP, WBC, and MPV in the sepsis group were significantly higher than those in the control group (CRP:5.73 ± 4.19 vs. 2.50 ± 2.77 mg/L; WBC: 13.47 ± 12.35 vs. 6.83 ± 3.55 × 10 /L; MPV: 11.20 ± 1.11 vs. 8.90 ± 0.68 fL), the level of PLT was significantly lower than those in the control group (PLT: 161.00 ± 38.51 vs. 241.50 ± 49.85 × 10 /L) ( < 0.05). Pearson correlation analysis showed that the expression of LL37 was negatively correlated with PLT level ( = -0.9347, < 0.0001), and positively correlated with MPV level ( = 0.9463, < 0.0001). ROC curve analysis showed that the area under curve of LL37 for diagnosis of early onset sepsis was 0.875, the prediction probability was 0.7, the sensitivity was 90.0% and the specificity was 80.0%.
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This article was submitted to Neonatology, a section of the journal Frontiers in Pediatrics
These authors have contributed equally to this work
Reviewed by: Manuela Simonato, University Hospital of Padua, Italy; Pradeep Suryawanshi, Bharati Vidyapeeth Deemed University, India
Edited by: Luca Vedovelli, University of Padua, Italy
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2022.903319