Peri‐implant diseases and systemic inflammation: A preliminary analysis from a cross‐sectional survey of patients with hypertension

• Published in: Journal of periodontology (1970) Vol. 95; no. 6; pp. 525 - 534
• Main Authors: Orlandi, Marco, Pranno, Nicola, Patel, Vipul, Papi, Piero, Di Murro, Bianca, Pompa, Giorgio, Polimeni, Antonella, Letizia, Claudio, Suvan, Jeanie, D'Aiuto, Francesco
• Format: Journal Article
• Language: English
• Published: United States 01.06.2024
• Subjects: Adult; Age Factors; Aged; C-Reactive Protein - analysis; Cross-Sectional Studies; C‐reactive protein; Dental Implants; Female; Humans; Hypertension - complications; inflammation; Inflammation - blood; Male; Middle Aged; mucositis; Mucositis - blood; Mucositis - etiology; Peri-Implantitis - blood; Periodontitis - blood; Periodontitis - complications; peri‐implantitis; Sex Factors; Smoking; Stomatitis - blood; Stomatitis - etiology; mucositis; peri‐implantitis; inflammation; C‐reactive protein; dental implants
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1002/JPER.21-0338

Background The aim of this study was to investigate the association between peri‐implant diseases and systemic inflammation assessed by serum C‐reactive protein (CRP) levels in a sample of patients with hypertension. Methods A total of 151 participants with hypertension were included in a cross‐sectional study. The population was divided into six groups according to their peri‐implant and periodontal status (healthy controls, mucositis, peri‐implantitis, periodontitis, periodontitis and mucositis, periodontitis, and peri‐implantitis). Linear, logistic regression, and correlation analyses were performed. Results CRP levels were statistically significantly higher in participants with periodontitis alone (median 3.2 mg/L, interquartile range [IQR] 1.8, p = 0.012), combined with mucositis (3.10 mg/L, IQR 2.35, p < 0.001) or peri‐implantitis (2.7 mg/L, IQR 2.53, p = 0.002) when compared to the healthy controls (1 mg/L, IQR 1.2). This association was independent of age, sex, smoking status, and adiposity differences. Participants with periodontitis with and without peri‐implant diseases had the greatest odds of exhibiting CRP > 3 mg/L (odds ratio = 7.3, 95% confidence interval 1.6–33.9). Conclusions Peri‐implant diseases are associated with systemic inflammation, but the nature of the association should be further investigated.