Genetic effect of single nucleotide polymorphisms in growth hormone receptor gene on the risk of non‐syndromic mandibular prognathism in the Korean population

Objectives To evaluate the association of three single‐nucleotide polymorphisms (SNPs) of growth hormone receptor (GHR) gene with mandibular prognathism (MP) and relationships between mandibular morphology and GHR gene SNPs in the Korean population. Materials and methods A total of 325 subjects were...

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Published inOrthodontics & craniofacial research Vol. 25; no. 3; pp. 437 - 446
Main Authors Park, Hae Jeong, Ahn, Sung Jea, Jang, Jinung, Kim, Su‐Jung, Park, Young‐Guk, Kim, Kyung‐A
Format Journal Article
LanguageEnglish
Published Malden Wiley Subscription Services, Inc 01.08.2022
Subjects
genetic association
Genotyping
Growth hormone
growth hormone receptor gene
Growth hormones
Mandible
mandibular prognathism
Morphogenesis
Morphology
Prognathism
single nucleotide polymorphisms
Single-nucleotide polymorphism
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Summary:Objectives To evaluate the association of three single‐nucleotide polymorphisms (SNPs) of growth hormone receptor (GHR) gene with mandibular prognathism (MP) and relationships between mandibular morphology and GHR gene SNPs in the Korean population. Materials and methods A total of 325 subjects were divided into two groups based on sagittal maxillomandibular relationship by the lateral cephalography: the MP and control groups. From the SNPs in the GHR gene, three SNPs (rs6180, rs6182 and rs6184) were selected. SNP genotyping was performed using direct sequencing. The craniofacial measurements of lateral cephalography were analysed. Results We found a lack of association between GHR and MP. However, in the analysis according to the values of cephalometric measurements, rs6180 was significantly associated with ANB, SNB, effective mandibular length and SNMP in females. Additionally, rs6182 and rs6184 were significantly associated with ramal height in males. Conclusion Growth hormone receptor SNPs may affect not only the sagittal development of mandible but also the vertical development of ramal height, and GHR SNPs may gender‐differently influence mandibular morphology. This finding supports that the GHR might be susceptible on mandibular morphogenesis in the Korean population.
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ISSN:1601-6335
1601-6343
DOI:10.1111/ocr.12554