THE ROLE OF STROMAL COMPONENTS AND CA++ATPASE IN PLEOMORPHIC ADENOMA AND ADENOID CYSTIC CARCINOMA

• Published in: Nippon Jibi Inkoka Gakkai Kaiho Vol. 94; no. 6; pp. 823 - 828
• Main Authors: MORITA, TAKAMASA, HIRANO, TOSHIKAZU, ASANO, GORO, UGE, KURATA
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Oto-Rhino-Laryngological Society of Japan, Inc 1991
• Subjects: Adenoma, Pleomorphic - enzymology; Adenoma, Pleomorphic - pathology; Calcium-Transporting ATPases - metabolism; Calcium-Transporting ATPases - physiology; Carcinoma, Adenoid Cystic - enzymology; Carcinoma, Adenoid Cystic - pathology; Cell Division; Collagen - metabolism; Humans; Proteoglycans - metabolism; Salivary Gland Neoplasms - enzymology; Salivary Gland Neoplasms - pathology; Staining and Labeling - methods
• ISSN: 0030-6622; 1883-0854
• DOI: 10.3950/jibiinkoka.94.823

In order to clarify the neoplastic-mesenchymal cell interaction, tumor structures were histologically classified into duct, solid and scattered types, and stromal changes were observed in each type with histochemical techniques. The quantitative and qualitative differences of the stromal components as proteoglycan and collagen were histochemically differed in these morphological features. Ca++ATPase was ultrastructurally localized on the plasma membrane of myoepithelial cell in salivary glands. The activity of Ca++ATPase changes in tumor cell differentiation of pleomorphic adenoma and adenoid cystic carcinoma. These results suggest that the stromal components and Ca++ATPase play an important role on the tumor cell proliferation and differentiation in these tumors.