Non-reciprocal control of rhythmic activity in respiratory-modulated XII motoneurons

To elucidate the nature of phasic respiratory inputs to hypoglossal (XII) motoneurons, we assessed the phasic changes in membrane resistance (RN) in inspiratory- and expiratory-modulated motoneurons. In expiratory motoneurons, RN was consistently lower in inspiration than in expiration and intracell...

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Bibliographic Details
Published inNeuroreport Vol. 6; no. 15; p. 2085
Main Authors Woch, G, Kubin, L
Format Journal Article
LanguageEnglish
Published England 23.10.1995
Subjects
Animals
Cats
gamma-Aminobutyric Acid - pharmacology
Glycine - pharmacology
Hypoglossal Nerve - physiology
Membrane Potentials - physiology
Motor Neurons - physiology
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Summary:To elucidate the nature of phasic respiratory inputs to hypoglossal (XII) motoneurons, we assessed the phasic changes in membrane resistance (RN) in inspiratory- and expiratory-modulated motoneurons. In expiratory motoneurons, RN was consistently lower in inspiration than in expiration and intracellular injection of negative current reversed the phasic hyperpolarizing membrane potential wave in inspiration. In inspiratory motoneurons, RN changed less but also was minimal in inspiration. In these neurons, injection of a negative current sufficient to reverse a lingual nerve-evoked IPSP did not reverse the phasic expiratory hyperpolarization. Thus, respiratory-related inhibitory inputs are non-reciprocal in inspiratory and expiratory XII motoneurons, with inspiratory motoneurons probably lacking a somatic, amino acid-mediated inhibitory input in expiration.
ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-199510010-00031