CHF: circulatory homeostasis gone awry

The role of the renin-angiotensin-aldosterone system (RAAS) is integral to salt and water retention, particularly by the kidneys. Over time, positive sodium balance leads first to intra- and then to extravascular volume expansion, with subsequent symptomatic heart failure. This report examines the r...

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Bibliographic Details
Published inCongestive heart failure (Greenwich, Conn.) Vol. 8; no. 1; p. 37
Main Authors Weber, Karl T, Burlew, Brad S, Davis, Richard C, Newman, Kevin P, D'Cruz, Ivan A, Hawkins, Ralph G, Wall, Barry M, Parker, Robert B
Format Journal Article
LanguageEnglish
Published United States 01.01.2002
Subjects
Blood Circulation - physiology
Blood Volume - physiology
Heart Failure - blood
Heart Failure - physiopathology
Homeostasis - physiology
Humans
Natriuresis - physiology
Posture - physiology
Renin-Angiotensin System - physiology
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Summary:The role of the renin-angiotensin-aldosterone system (RAAS) is integral to salt and water retention, particularly by the kidneys. Over time, positive sodium balance leads first to intra- and then to extravascular volume expansion, with subsequent symptomatic heart failure. This report examines the role of the RAAS in regulating a less well recognized component essential to circulatory homeostasis--central blood volume. The regulation of central blood volume draws on integrative cardiorenal physiology and a key role played by the RAAS in its regulation. In presenting insights into the role of the RAAS in regulating central blood volume, this review also addresses other sodium-retaining states with a predisposition to edema formation, such as cirrhosis and nephrosis.
ISSN:1527-5299
DOI:10.1111/j.1527-5299.2002.00720.x