Quality and rapidity of anticoagulation in patients with acute pulmonary embolism undergoing mechanical thrombectomy

The primary objective of our study was to determine the proportion of intermediate-risk PE patients undergoing mechanical thrombectomy (MT) who achieved therapeutic anticoagulation (AC) at the time of the procedure. The salient findings of our study showed that only a minority of patients (14.3%) we...

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Published inThe American heart journal Vol. 267; pp. 91 - 94
Main Authors Zhang, Robert S, Ho, Alvin M, Elbaum, Lindsay, Greco, Allison A, Hall, Sylvie, Postelnicu, Radu, Mukherjee, Vikramjit, Maqsood, Muhammad H, Keller, Norma, Alviar, Carlos L, Bangalore, Sripal
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 01.01.2024
Subjects
Anticoagulants
Embolism
Patients
Pulmonary embolisms
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Summary:The primary objective of our study was to determine the proportion of intermediate-risk PE patients undergoing mechanical thrombectomy (MT) who achieved therapeutic anticoagulation (AC) at the time of the procedure. The salient findings of our study showed that only a minority of patients (14.3%) were in the therapeutic range by ACT at the time of MT (primary outcome). Furthermore, in this higher-risk PE cohort selected for MT, 18.2% of patients were subtherapeutic after initially reaching therapeutic AC, 43% experienced supratherapeutic AC at some point before MT, and less than half (43%) attained therapeutic AC at 6 hours, highlighting the necessity for optimizing anticoagulation practices in acute PE.
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ISSN:0002-8703
1097-6744
1097-6744
DOI:10.1016/j.ahj.2023.10.001