Leukaemia in children with Down's syndrome

Between 1971 and 1981 756 children were diagnosed to have leukaemia in Hungary. Of these, 17 had Down's syndrome. Analyzing the clinical course of their leukaemia revealed a low remission rate and very poor survival in these patients. Down's syndrome seems to present a special high-risk fe...

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Bibliographic Details
Published inOncology Vol. 40; no. 4; p. 280
Main Authors Kardos, G, Révész, T, Bulin, A, Fekete, G, Vargha, M, Schuler, D
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1983
Subjects
Blood Cell Count
Child
Down Syndrome - complications
Down Syndrome - mortality
Female
Humans
Hungary
Leukemia - complications
Leukemia, Monocytic, Acute - complications
Male
Maternal Age
Probability
Registries
Sex Factors
Hungary
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Summary:Between 1971 and 1981 756 children were diagnosed to have leukaemia in Hungary. Of these, 17 had Down's syndrome. Analyzing the clinical course of their leukaemia revealed a low remission rate and very poor survival in these patients. Down's syndrome seems to present a special high-risk feature, for early death or relapse into leukaemia, which is only partially explained by the accompanying abnormalities.
ISSN:0030-2414
DOI:10.1159/000225743