Familial autoimmune myasthenia gravis

We describe a family with parental consanguinity and five of 10 siblings affected by late-onset autoimmune myasthenia gravis. We propose a genetic mechanism as a predisposing factor in this family. Our analysis excludes the major histocompatibility complex, the beta subunit of the acetylcholine rece...

Full description

Saved in:
Bibliographic Details
Published inNeurology Vol. 44; no. 3 Pt 1; p. 551
Main Authors Bergoffen, J, Zmijewski, C M, Fischbeck, K H
Format Journal Article
LanguageEnglish
Published United States 01.03.1994
Subjects
Aged
Autoantibodies - genetics
Blotting, Southern
Female
HLA Antigens - genetics
Humans
Male
Myasthenia Gravis - genetics
Myasthenia Gravis - immunology
Pedigree
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Receptors, Antigen, T-Cell, alpha-beta - genetics
Receptors, Cholinergic - immunology
Online AccessGet more information

Cover

More Information
Summary:We describe a family with parental consanguinity and five of 10 siblings affected by late-onset autoimmune myasthenia gravis. We propose a genetic mechanism as a predisposing factor in this family. Our analysis excludes the major histocompatibility complex, the beta subunit of the acetylcholine receptor, and the T-cell receptor alpha and beta subunits as candidate genes for the disorder in this family.
ISSN:0028-3878
DOI:10.1212/WNL.44.3_Part_1.551