Studies of microsomal glucose-6-phosphatase on liver of irradiated rats

The activity of microsomal glucose-6-phosphatase (EC 3.1.3.9) on male rat liver was measured 1-9 days after whole-body gamma-irradiation. A marked fall of activity, expressed per whole liver, was observed reaching a minimum on the 4th day following irradiation. The enzyme activity is partially and m...

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Bibliographic Details
Published inEnzyme (Basel) Vol. 25; no. 4; p. 250
Main Authors Bernard, P, Neveux, Y, Rocquet, G, Drouet, J
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1980
Subjects
Animals
Cysteamine - pharmacology
Gamma Rays
Glucose-6-Phosphatase - metabolism
Liver - drug effects
Liver - radiation effects
Male
Microsomes, Liver - enzymology
Rats
Time Factors
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Summary:The activity of microsomal glucose-6-phosphatase (EC 3.1.3.9) on male rat liver was measured 1-9 days after whole-body gamma-irradiation. A marked fall of activity, expressed per whole liver, was observed reaching a minimum on the 4th day following irradiation. The enzyme activity is partially and momentarily restored (on day 7), before a new decrease occurred. Furthermore, when the results are expressed per milligram of microsomal proteins, there was no change. Cysteamine, when injected in vivo, kept up the glucose-6-phosphatase of whole liver. On day 4, a histochemical demonstration of the enzyme in liver cells is in accordance with enzyme measures. These observations suggested that the enzyme quantity was altered during the acute radiation syndrome in the rat.
ISSN:0013-9432
DOI:10.1159/000459260