Morphological platelet anomalies in thrombotic thrombocytopenic purpura

A patient with thrombotic thrombocytopenic purpura was treated with 8 U of fresh frozen plasma, resulting in a rapid improvement in her condition and subsequently followed by a prolonged clinical remission. The transmission and scanning electron microscopic examinations of the platelets performed be...

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Bibliographic Details
Published inActa haematologica Vol. 67; no. 2; p. 119
Main Authors Aderka, D, Djaldetti, M, Shoenfeld, Y, Shaklai, M, Santo, M, Berliner, S, Weinberger, A, Pinkhas, J
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1982
Subjects
Blood Coagulation Factors - antagonists & inhibitors
Blood Platelets - pathology
Blood Platelets - ultrastructure
Blood Transfusion
Female
Humans
Middle Aged
Plasma
Platelet Activating Factor
Purpura, Thrombotic Thrombocytopenic - blood
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Summary:A patient with thrombotic thrombocytopenic purpura was treated with 8 U of fresh frozen plasma, resulting in a rapid improvement in her condition and subsequently followed by a prolonged clinical remission. The transmission and scanning electron microscopic examinations of the platelets performed before treatment demonstrated marked anomalies of the platelet morphology, namely, an increased number of abnormally elongated pseudopods with terminal knobs, a decreased number of platelet granules and excess of glycogen and marked anisocytosis. These anomalies remained unchanged when reexamined 2 months after the achievement of the clinical remission. The question whether these platelet abnormalities are an integral part of thrombotic thrombocytopenic purpura and play a role in its pathogenesis, is raised.
ISSN:0001-5792
1421-9662
DOI:10.1159/000207037