Genomic screening of head and neck cancer and its implications for therapy planning

• Published in: European archives of oto-rhino-laryngology Vol. 263; no. 4; pp. 297 - 304
• Main Author: AKERVALL, Jan
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.04.2006
• Subjects: Biological and medical sciences; Biomarkers, Tumor; Cytogenetic Analysis; Disease Progression; Gene Expression Profiling; Genomic Imprinting; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - therapy; Medical sciences; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Prognosis; Spectral Karyotyping; Tumors; Human; Squamous cell carcinoma; cDNA micro array; CGH; Genomics; Malignant tumor; Review; Medical screening; Complementary DNA; Gene; ENT disease; Head and neck cancer; Gene profiling

Despite great technical improvements in radiotherapy and surgery, survival for patients with squamous cell carcinoma of the head and neck (SCCHN) has still not improved significantly over the last decades. Management of SCCHN has mainly been based on the TNM staging and site over this time period, e...