Behçet’s Disease with Extremely High Levels of Urinary β2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment

• Published in: The Tohoku Journal of Experimental Medicine Vol. 254; no. 4; pp. 283 - 286
• Main Authors: Ogino, Ryohei, Shimada, Karin, Narai, Daiki, Goto, Masanori, Sato, Katsuhiro, Katsuta, Yoshihisa, Shiigi, Akimasa, Ueda, Juri, Oyama, Chika, Fujikawa, Yuko, Miyazawa, Isabelle, Ohara, Takahiro, Sumitomo, Kazuhiro, Sato, Shigeru, Koinuma, Nobuo, Kanno, Atsuhiro, Furukawa, Katsutoshi
• Format: Journal Article
• Language: English
• Published: Japan Tohoku University Medical Press 2021
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Behcet Syndrome - drug therapy; Behçet’s disease; creatinine; Humans; Male; Middle Aged; non-steroidal anti-inflammatory drug; Pharmaceutical Preparations; renal dysfunction; β2-microglobulin; creatinine; renal dysfunction; Behçet’s disease; β2-microglobulin; non-steroidal anti-inflammatory drug
• ISSN: 0040-8727; 1349-3329
• DOI: 10.1620/tjem.254.283

Behçet’s disease is an inflammatory disease which manifests itself as various symptoms, such as uveitis, oral and genital aphthae, erythema nodosa, gastro-intestinal ulcerations and encephalopathy. Among the manifestations, renal dysfunction is reported in some percentage of the patients with this disorder. We experienced a middle-aged male with Behçet’s disease who showed an extremely high level of urinary β2-microglulin, which is one of the markers of renal dysfunction, despite normal serum creatinine levels. The patient was on non-steroidal anti-inflammatory drug (NSAID) therapy for 7 weeks, and this could have affected his renal dysfunction. The present report suggests that renal injury should not be underestimated in patients with Behçet’s disease, especially in patients using NSAIDs.