Transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides

The selective transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides is described. The N-methyl group of the parent tertiary amines was replaced by alkenyl units of the butenolides; and a series of butenolide-containing tertiary enamines were obtained in moderate to good yields. Int...

Full description

Saved in:
Bibliographic Details
Published inChinese chemical letters Vol. 24; no. 9; pp. 837 - 839
Main Authors Wei, Meng-Xue, Gao, Xiao-Hui, Li, Tian-Cai, Fan, Chun-An, Li, Xue-Qiang
Format Journal Article
LanguageEnglish
Published NEW YORK Elsevier B.V 01.09.2013
Elsevier
Subjects
Amination
Butenolides
Chemistry
Chemistry, Multidisciplinary
Enamines
HeLa细胞系
IC50
N-甲基
Physical Sciences
Science & Technology
Tertiary amine
Transalkylation
丁烯酸
叔胺
抗癌活性
烷基转移
链烯基
Tertiary amine
Butenolides
Amination
Enamines
Transalkylation
RESIN
RUBROLIDES
REDUCTION
DEMETHYLATION
QUATERNARY AMMONIUM-SALTS
CLEAVAGE
Online AccessGet full text

Cover

More Information
Summary:The selective transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides is described. The N-methyl group of the parent tertiary amines was replaced by alkenyl units of the butenolides; and a series of butenolide-containing tertiary enamines were obtained in moderate to good yields. Interestingly, the product 2b has shown a promising anticancer activity against HeLa cell lines （IC50 = 0.19μmol/L）.
Bibliography:Amination Enamines Butenolides Tertiary amine Transalkylation
11-2710/O6
The selective transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides is described. The N-methyl group of the parent tertiary amines was replaced by alkenyl units of the butenolides; and a series of butenolide-containing tertiary enamines were obtained in moderate to good yields. Interestingly, the product 2b has shown a promising anticancer activity against HeLa cell lines （IC50 = 0.19μmol/L）.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.05.003