Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma

• Published in: Anticancer research Vol. 37; no. 7; pp. 3423 - 3427
• Main Authors: Shackelford, Rodney E, Abdulsattar, Jehan, Wei, Eric X, Cotelingam, James, Coppola, Domenico, Herrera, Guillermo A
• Format: Journal Article
• Language: English
• Published: Greece 01.07.2017
• Subjects: Adenoma, Oxyphilic - metabolism; Carcinoma, Renal Cell - metabolism; Cystathionine beta-Synthase - metabolism; Cytokines - metabolism; Humans; Hydrogen Sulfide - metabolism; Kidney - metabolism; Kidney Neoplasms - metabolism; Nicotinamide Phosphoribosyltransferase - metabolism; nicotinamide phosphoribosyltransferase; Renal cancer; Fuhrman grade; cystathionine-β-synthase
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.11709

Renal oncocytomas (ROs), and clear cell (RCC) and urothelial carcinomas (UC), are common renal neoplasms. Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of NAD synthesis and its expression is increased in several tumors. Nampt concomitantly regulates hydrogen sulfide (H S)-synthesizing enzyme levels, including cystathionine-β-synthase (CBS). We used tissue microarrays to examine Nampt and the H S-synthesizing enzyme CBS protein levels in benign kidney, RCC, UC and ROs. Compared to benign kidney, all three neoplasms showed increased Nampt and CBS protein levels, with the levels increasing in RCC at higher Fuhrman grades. H S is known to ameliorate chronic renal failure but, as yet, no role for H S in renal neoplasia has been demonstrated. Here, we showed, for the first time, that Nampt, CBS and, likely, H S likely play a role in malignant and benign neoplastic renal disease.